Metalloprotease enzyme play an important role in tissue remolding associated with various process such as morphogenesis, angiogenesis, tissue repair, arthritis and metastasis. In cancer elaboration of metalloprotease takes place . In present study the docking study was performed on 14 Schiff bases of dapsone and their substituted 2-azetidinone with metalloprotease enzyme. The binding conformation of Schiff bases of dapsone and their substituted 2-azetidinone for the inhibition of metalloprotease enzyme for predicting the role of dapsone and their derivative as new potential inhibitors useful as anticancer agent was performed by using Molegro Virtual Docker MVD (Molegro Aps). The binding was determined and predicted by molecular docking. Best docking scores were shown by molecule 1a and 2c.
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